University of California San Francisco

Wenhan Chang, PhD
Wenhan Chang, PhD

Professor, Medicine
School of Medicine

Address

1700 Owens Street, #374
San Francisco, CA 94158
United States

Email: [email protected]
Phone: 415-575-0558
Fax: 415-575-0593

ORCID: 0000-0001-6583-7176

Education

Institution Degree Dept or School End Date
State University of New York PhD Physiology/Electrophysiology
University of California San Francisco Post-doc Endocrinology

Grants and Funding

  • Vitamin D and beta-amyloid signaling in hyperparathyroidism | NIH/NIA | 2023-04-01 - 2028-03-31 | Role: Co-Principal Investigator
  • FRACTURE CURB: Combined long-acting PTH and calcimimetics actions on skeletal anabolism | VA BLR&D | 2021-10-01 - 2025-09-30 | Role: Principal Investigator
  • BLR&D Research Career Scientist Award | NIH | 2019-10-01 - 2024-09-30 | Role: Principal Investigator
  • UCSF Core Center for Musculoskeletal Biology in Medicine | NIH NIAMS | 2019-10-01 - 2024-09-30 | Role: Director of Skeletal Biology and Biomechanics Core
  • Regulation of Parathyroid Functions By G-Protein Coupled Receptors | NIH | 2019-09-12 - 2024-08-31 | Role: Principal Investigator
  • ShEEP Request for NanoString GeoMx Digital Spatial Profiling System | VA BLR&D | 2022-10-01 - 2023-09-30 | Role: Principal Investigator
  • Regulation of PTH secretion by TRPC1 | NIH | 2019-04-01 - 2023-03-31 | Role: Co-Principal Investigator
  • Regulation of parathyroid function by the amyloid precursor protein | NIH | 2021-05-01 - 2023-01-31 | Role: Co-Principal Investigator
  • A novel treatment for bone fracture repair | NIH | 2017-10-01 - 2021-09-30 | Role: Principal Investigator
  • The 4th Symposium on The Extracellular Calcium-Sensing Receptor | NIH | 2020-03-01 - 2021-02-28 | Role: Principal Investigator
  • ShEEP Equipment Request for GeoMx? Digital Spatial Profiler System | NIH | 2019-09-01 - 2020-09-30 | Role: Principal Investigator
  • Combined PTH and Calcimimetic Therapy and Its Mechanisms for Osteoanabolism | NIH | 2015-02-11 - 2020-06-30 | Role: Principal Investigator
  • UCSF Core Center for Musculoskeletal Biology and Medicine | NIH | 2014-07-01 - 2020-03-31 | Role: Co-director of Skeletal Biology Core
  • ShEEP Equipment Request for nCounter Max Analysis System | NIH | 2019-01-01 - 2019-09-30 | Role: Principal Investigator
  • ShEEP Request for Atomic Force Microscope (BRUKER INNOVA2-SYS) | NIH | 2018-01-01 - 2018-09-30 | Role: Principal Investigator
  • The Role of CaSR and GABA-B-R in Neuronal Responses to Ischemic Brain Injury | NIH | 2013-04-01 - 2017-03-31 | Role: Principal Investigator
  • ShEEP Request for SCANCO Medical VivaCT 80 preclinical micro-computed tomography (pCT) system | NIH | 2016-05-01 - 2016-09-30 | Role: Principal Investigator
  • CALCIUM-SENSING RECEPTORS AND GROWTH PLATE DEVELOPMENT | NIH | 2002-02-15 - 2014-03-31 | Role: Principal Investigator
  • INTERACTIONS BETWEEN GABA B AND CA2+-SENSING RECEPTORS | NIH | 2007-03-06 - 2010-02-28 | Role: Principal Investigator
  • Resolution of Stage-Specific Growth Plate Chondrocytes | NIH | 2003-09-25 - 2006-06-30 | Role: Principal Investigator

Publications

MOST RECENT PUBLICATIONS FROM A TOTAL OF 91
  1. Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice.
    Cheng Z, Li A, Tu CL, Maria CS, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W| | PubMed
  2. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion.
    Centeno PP, Herberger A, Mun HC, Tu C, Nemeth EF, Chang W, Conigrave AD, Ward DT| | PubMed
  3. Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent β-catenin stabilization in osteoblasts.
    Rybchyn MS, Islam KS, Brennan-Speranza TC, Cheng Z, Brennan SC, Chang W, Mason RS, Conigrave AD| | PubMed
  4. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport.
    Munson S, Wang Y, Chang W, Bikle DD| | PubMed
  5. Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR.
    Zhang M, Yang H, Wan X, Lu L, Zhang J, Zhang H, Ye T, Liu Q, Xie M, Liu X, Yu S, Guo S, Chang W, Wang M| | PubMed
  6. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
    Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV| | PubMed
  7. Calcium-Sensing Receptor Regulates Epidermal Intracellular Ca2+ Signaling and Re-Epithelialization after Wounding.
    Tu CL, Celli A, Mauro T, Chang W| | PubMed
  8. Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons.
    Sun X, Tang L, Winesett S, Chang W, Cheng SX| | PubMed
  9. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes.
    Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS| | PubMed
  10. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein.
    Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J| | PubMed
91
View all 91 Publications
MOST RECENT PUBLICATIONS FROM A TOTAL OF 91
  1. Large library docking identifies positive allosteric modulators of the calcium-sensing receptor.
    Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G| | PubMed
  2. The osteocytic actions of glucocorticoids on bone mass, mechanical properties, or perilacunar remodeling outcomes are not rescued by PTH(1-34).
    Yee CS, Meliadis C, Kaya S, Chang W, Alliston T| | PubMed
  3. Linoleic acid blunts early osteoblast differentiation and impairs oxidative phosphorylation in vitro.
    Nesbeth PC, Ziegler TR, Tripathi AK, Dabeer S, Weiss D, Hao L, Smith MR, Jones DP, Maner-Smith KM, Tu CL, Chang W, Weitzmann MN, Alvarez JA| | PubMed
  4. Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice.
    Tang LQ, Fraebel J, Jin S, Winesett SP, Harrell J, Chang WH, Cheng SX| | PubMed
  5. FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice.
    Courbon G, Kentrup D, Thomas JJ, Wang X, Tsai HH, Spindler J, Von Drasek J, Ndjonko LM, Martinez-Calle M, Lynch S, Hivert L, Wang X, Chang W, Feng JQ, David V, Martin A| | PubMed
  6. Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation.
    Courbon G, Thomas JJ, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, Hunt-Tobey B, Mehta R, Isakova T, Chang W, Creemers JWM, Ji P, Martin A, David V| | PubMed
  7. Digital spatial profiling of human parathyroid tumors reveals cellular and molecular alterations linked to vitamin D deficiency.
    Tu CL, Chang W, Sosa JA, Koh J| | PubMed
  8. Immune Reconstitution Bone Loss Exacerbates Bone Degeneration Due to Natural Aging in a Mouse Model.
    Weitzmann MN, Weiss D, Vikulina T, Roser-Page S, Yu K, McGee-Lawrence ME, Tu CL, Chang W, Ofotokun I| | PubMed
  9. Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells.
    Schepelmann M, Ranieri M, Lopez-Fernandez I, Webberley TS, Brennan SC, Yarova PL, Graca J, Hanif UK, Müller C, Manhardt T, Salzmann M, Quasnichka H, Price SA, Ward DT, Gilbert T, Matchkov VV, Fenton RA, Herberger A, Hwong J, Santa Maria C, Tu CL, Kallay E, Valenti G, Chang W, Riccardi D| | PubMed
  10. Precise druggability of the PTH type 1 receptor.
    Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP| | PubMed
  11. Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.
    White AD, Peña KA, Clark LJ, Maria CS, Liu S, Jean-Alphonse FG, Lee JY, Lei S, Cheng Z, Tu CL, Fang F, Szeto N, Gardella TJ, Xiao K, Gellman SH, Bahar I, Sutkeviciute I, Chang W, Vilardaga JP| | PubMed
  12. FBW7 couples structural integrity with functional output of primary cilia.
    Petsouki E, Gerakopoulos V, Szeto N, Chang W, Humphrey MB, Tsiokas L| | PubMed
  13. The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells.
    Rybchyn MS, Brennan-Speranza TC, Mor D, Cheng Z, Chang W, Conigrave AD, Mason RS| | PubMed
  14. Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels.
    Martiszus BJ, Tsintsadze T, Chang W, Smith SM| | PubMed
  15. Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice.
    Mayer CA, Roos B, Teske J, Wells N, Martin RJ, Chang W, Pabelick CM, Prakash YS, MacFarlane PM| | PubMed
  16. Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling.
    Egli-Spichtig D, Zhang MYH, Li A, Pastor Arroyo EM, Hernando N, Wagner CA, Chang W, Perwad F| | PubMed
  17. Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis.
    Jäger E, Murthy S, Schmidt C, Hahn M, Strobel S, Peters A, Stäubert C, Sungur P, Venus T, Geisler M, Radusheva V, Raps S, Rothe K, Scholz R, Jung S, Wagner S, Pierer M, Seifert O, Chang W, Estrela-Lopis I, Raulien N, Krohn K, Sträter N, Hoeppener S, Schöneberg T, Rossol M, Wagner U| | PubMed
  18. Control of PTH secretion by the TRPC1 ion channel.
    Onopiuk M, Eby B, Nesin V, Ngo P, Lerner M, Gorvin CM, Stokes VJ, Thakker RV, Brandi ML, Chang W, Humphrey MB, Tsiokas L, Lau K| | PubMed
  19. PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism.
    Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP| | PubMed
  20. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney.
    Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP| | PubMed
  21. Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice.
    Cheng Z, Li A, Tu CL, Maria CS, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W| | PubMed
  22. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion.
    Centeno PP, Herberger A, Mun HC, Tu C, Nemeth EF, Chang W, Conigrave AD, Ward DT| | PubMed
  23. Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent β-catenin stabilization in osteoblasts.
    Rybchyn MS, Islam KS, Brennan-Speranza TC, Cheng Z, Brennan SC, Chang W, Mason RS, Conigrave AD| | PubMed
  24. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport.
    Munson S, Wang Y, Chang W, Bikle DD| | PubMed
  25. Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR.
    Zhang M, Yang H, Wan X, Lu L, Zhang J, Zhang H, Ye T, Liu Q, Xie M, Liu X, Yu S, Guo S, Chang W, Wang M| | PubMed
  26. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.
    Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV| | PubMed
  27. Calcium-Sensing Receptor Regulates Epidermal Intracellular Ca2+ Signaling and Re-Epithelialization after Wounding.
    Tu CL, Celli A, Mauro T, Chang W| | PubMed
  28. Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons.
    Sun X, Tang L, Winesett S, Chang W, Cheng SX| | PubMed
  29. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes.
    Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS| | PubMed
  30. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein.
    Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J| | PubMed
  31. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling.
    Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD| | PubMed
  32. Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone.
    Al-Dujaili SA, Koh AJ, Dang M, Mi X, Chang W, Ma PX, McCauley LK| | PubMed
  33. Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats.
    Zhang M, Wang H, Zhang J, Zhang H, Yang H, Wan X, Jing L, Lu L, Liu X, Yu S, Chang W, Wang M| | PubMed
  34. Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism.
    Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W| | PubMed
  35. Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney.
    Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA| | PubMed
  36. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure.
    Schepelmann M, Yarova PL, Lopez-Fernandez I, Davies TS, Brennan SC, Edwards PJ, Aggarwal A, Graça J, Rietdorf K, Matchkov V, Fenton RA, Chang W, Krssak M, Stewart A, Broadley KJ, Ward DT, Price SA, Edwards DH, Kemp PJ, Riccardi D| | PubMed
  37. Role of IGF-I signaling in muscle bone interactions.
    Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER| | PubMed
  38. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing.
    Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD| | PubMed
  39. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma.
    Yarova PL, Stewart AL, Sathish V, Britt RD, Thompson MA, P Lowe AP, Freeman M, Aravamudan B, Kita H, Brennan SC, Schepelmann M, Davies T, Yung S, Cholisoh Z, Kidd EJ, Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, T Ward JP, Kemp PJ, Pabelick CM, Prakash YS, Riccardi D| | PubMed
  40. Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon.
    Tang L, Peng M, Liu L, Chang W, Binder HJ, Cheng SX| | PubMed
  41. The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon.
    Aggarwal A, Prinz-Wohlgenannt M, Gröschel C, Tennakoon S, Meshcheryakova A, Chang W, Brown EM, Mechtcheriakova D, Kállay E| | PubMed
  42. Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling.
    Yang T, Zhang J, Cao Y, Zhang M, Jing L, Jiao K, Yu S, Chang W, Chen D, Wang M| | PubMed
  43. Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection.
    Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari MA, Chang W| | PubMed
  44. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation.
    Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD| | PubMed
  45. Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia.
    Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC| | PubMed
  46. Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis.
    Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB| | PubMed
  47. Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development.
    Wang Y, Bikle DD, Chang W| | PubMed
  48. Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury.
    Kim JY, Kim N, Yenari MA, Chang W| | PubMed
  49. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual.
    Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J| | PubMed
  50. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice.
    Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W| | PubMed
  51. The extracellular calcium-sensing receptor, CaSR, in fetal development.
    Riccardi D, Brennan SC, Chang W| | PubMed
  52. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function.
    Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD| | PubMed
  53. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover.
    Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM| | PubMed
  54. Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium.
    Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E| | PubMed
  55. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway.
    Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W| | PubMed
  56. Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression.
    Kim JY, Kim N, Yenari MA, Chang W| | PubMed
  57. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A.
    Tu CL, Chang W, Bikle DD| | PubMed
  58. Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function.
    Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL| | PubMed
  59. Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone.
    Chang W, Dvorak M, Shoback D| | PubMed
  60. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.
    Chang W, Tu C, Chen TH, Bikle D, Shoback D| | PubMed
  61. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes.
    Tu CL, Chang W, Xie Z, Bikle DD| | PubMed
  62. Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes.
    Cheng Z, Tu C, Rodriguez L, Chen TH, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W| | PubMed
  63. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons.
    Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D| | PubMed
  64. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone.
    Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM| | PubMed
  65. The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes.
    Tu CL, Chang W, Bikle DD| | PubMed
  66. WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes.
    Cheng Z, Tu C, Rodriguez L, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W| | PubMed
  67. Insulin-like growth factor-I is essential for embryonic bone development.
    Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD| | PubMed
  68. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes.
    Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W| | PubMed
  69. Extracellular calcium and parathyroid hormone-related peptide signaling modulate the pace of growth plate chondrocyte differentiation.
    Rodriguez L, Cheng Z, Chen TH, Tu C, Chang W| | PubMed
  70. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes.
    Tu CL, Chang W, Bikle DD| | PubMed
  71. Extracellular Ca2+-sensing in cartilage.
    Chang W, Rodriguez L, Chen TH, Tu C, Shoback D| | PubMed
  72. cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus).
    Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W, Shoback D| | PubMed
  73. Extracellular Ca2+-sensing receptors--an overview.
    Chang W, Shoback D| | PubMed
  74. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation.
    Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD| | PubMed
  75. Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells.
    Chang W, Tu C, Pratt S, Chen TH, Shoback D| | PubMed
  76. Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation.
    Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D| | PubMed
  77. Starvation amidst plenty--rickets and hypercalcemia in calcium receptor knockout mice.
    Shoback D, Chang W| | PubMed
  78. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes.
    Tu CL, Chang W, Bikle DD| | PubMed
  79. Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits.
    Chang W, Pratt SA, Chen TH, Tu CL, Mikala G, Schwartz A, Shoback D| | PubMed
  80. Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis.
    Gross C, De Baere E, Lo A, Chang W, Messiaen L| | PubMed
  81. Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C.
    Chang W, Chen TH, Pratt S, Shoback D| | PubMed
  82. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation.
    Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD| | PubMed
  83. Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes.
    Chang W, Pratt S, Chen TH, Shoback D| | PubMed
  84. Expression and signal transduction of calcium-sensing receptors in cartilage and bone.
    Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D| | PubMed
  85. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells.
    Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D| | PubMed
  86. Regulation of extracellular calcium-activated cation currents by cAMP in parathyroid cells.
    Chang W, Chen TH, Pratt S, Shoback D| | PubMed
  87. Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera.
    Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D| | PubMed
  88. Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists.
    Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D| | PubMed
  89. Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers.
    Chang W, Chen TH, Gardner P, Shoback D| | PubMed
  90. DPC blockade of transepithelial chloride absorption and single anion channels in teleost urinary bladder.
    Chang W, Loretz CA| | PubMed
  91. Identification of a stretch-activated monovalent cation channel from teleost urinary bladder cells.
    Chang WH, Loretz CA| | PubMed